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Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2

Posttranslational gene regulation requires a complex network of RNA–protein interactions. Cooperativity, which tunes response sensitivities, originates from protein–protein interactions in many systems. For RNA-binding proteins, cooperativity can also be mediated through RNA structure. RNA structura...

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Detalles Bibliográficos
Autores principales: Becker, Winston R., Jarmoskaite, Inga, Vaidyanathan, Pavanapuresan P., Greenleaf, William J., Herschlag, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521599/
https://www.ncbi.nlm.nih.gov/pubmed/30914482
http://dx.doi.org/10.1261/rna.068585.118