Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein

Viral and cellular double-stranded RNA (dsRNA) is recognized by cytosolic innate immune sensors, including RIG-I-like receptors. Some cytoplasmic dsRNA is commonly present in cells, and one source is mitochondrial dsRNA, which results from bidirectional transcription of mitochondrial DNA (mtDNA). He...

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Detalles Bibliográficos
Autores principales: Wiatrek, Dagmara M., Candela, Maria E., Sedmík, Jiří, Oppelt, Jan, Keegan, Liam P., O'Connell, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521600/
https://www.ncbi.nlm.nih.gov/pubmed/30894411
http://dx.doi.org/10.1261/rna.069625.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521600/
https://www.ncbi.nlm.nih.gov/pubmed/30894411
http://dx.doi.org/10.1261/rna.069625.118

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