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Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca(2+) Channel Ca(2+) Spike Propagation to the Soma

Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the c...

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Detalles Bibliográficos
Autores principales: Wild, Angela R., Sinnen, Brooke L., Dittmer, Philip J., Kennedy, Matthew J., Sather, William A., Dell’Acqua, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521872/
https://www.ncbi.nlm.nih.gov/pubmed/30917310
http://dx.doi.org/10.1016/j.celrep.2019.03.005