Cargando…

Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

BACKGROUND: The early life environment may influence susceptibility to obesity and metabolic disease in later life through epigenetic processes. SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. We tested the hypothesis that methylation of the SLC6A4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lillycrop, Karen A., Garratt, Emma S., Titcombe, Philip, Melton, Phillip E., Murray, Robert J. S., Barton, Sheila J., Clarke-Harris, Rebecca, Costello, Paula M., Holbrook, Joanna D., Hopkins, James C., Childs, Caroline E., Paras-Chavez, Carolina, Calder, Philip C., Mori, Trevor A., Beilin, Lawrie, Burdge, Graham C., Gluckman, Peter D., Inskip, Hazel M., Harvey, Nicholas C., Hanson, Mark A., Huang, Rae-Chi, Cooper, Cyrus, Godfrey, Keith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522375/ https://www.ncbi.nlm.nih.gov/pubmed/30622309 http://dx.doi.org/10.1038/s41366-018-0254-3

Ejemplares similares

ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity
por: Lillycrop, Karen, et al.
Publicado: (2017)

Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey
por: Curtis, Elizabeth M, et al.
Publicado: (2017)

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function
por: Titcombe, Philip, et al.
Publicado: (2021)

Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years
por: Murray, Robert, et al.
Publicado: (2021)

DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years
por: Murray, Robert, et al.
Publicado: (2016)

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
por: Godfrey, Keith M., et al.
Publicado: (2011)

Tissue-Specific 5′ Heterogeneity of PPARα Transcripts and Their Differential Regulation by Leptin
por: Garratt, Emma S., et al.
Publicado: (2013)

In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of Association
por: Barton, Sheila J., et al.
Publicado: (2019)

Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour
por: Lillycrop, Karen A, et al.
Publicado: (2015)

Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort(1)
por: Händel, Mina N, et al.
Publicado: (2016)

Supplementation with N-3 Long-Chain Polyunsaturated Fatty Acids or Olive Oil in Men and Women with Renal Disease Induces Differential Changes in the DNA Methylation of FADS2 and ELOVL5 in Peripheral Blood Mononuclear Cells
por: Hoile, Samuel P., et al.
Publicado: (2014)

Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood
por: Huang, R C, et al.
Publicado: (2015)

Vegetarian Diet during Pregnancy Is Not Associated with Poorer Cognitive Performance in Children at Age 6–7 Years
por: Crozier, Sarah R., et al.
Publicado: (2019)

Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk
por: Rauschert, Sebastian, et al.
Publicado: (2019)

Maternal Plasma Phosphatidylcholine Fatty Acids and Atopy and Wheeze in the Offspring at Age of 6 Years
por: Pike, Katharine C., et al.
Publicado: (2012)

Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial
por: Antoun, Elie, et al.
Publicado: (2020)

DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake
por: Antoun, E, et al.
Publicado: (2021)

Magnetic resonance imaging of pulse wave velocity in children aged 9 years to assess maternal influences on aortic stiffness in the offspring
por: Bryant, Jennifer A, et al.
Publicado: (2012)

Preconception Maternal Iodine Status Is Positively Associated with IQ but Not with Measures of Executive Function in Childhood
por: Robinson, Sian M, et al.
Publicado: (2018)

Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans
por: West, Annette L., et al.
Publicado: (2020)

Dietary Supplementation with Transgenic Camelina sativa Oil Containing 20:5n-3 and 22:6n-3 or Fish Oil Induces Differential Changes in the Transcriptome of CD3(+) T Lymphocytes
por: West, Annette L., et al.
Publicado: (2021)

Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells
por: Sibbons, Charlene M., et al.
Publicado: (2018)

Differential DNA methylation of steatosis and non-alcoholic fatty liver disease in adolescence
por: Melton, Phillip E., et al.
Publicado: (2023)

Correction of unexpected distributions of P values from analysis of whole genome arrays by rectifying violation of statistical assumptions
por: Barton, Sheila J, et al.
Publicado: (2013)

Bridging the gap between epigenetics research and nutritional public health interventions
por: Burdge, Graham C, et al.
Publicado: (2010)

Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial
por: Fisk, Helena L., et al.
Publicado: (2022)

The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism
por: von Gerichten, Johanna, et al.
Publicado: (2021)

Fatty acid composition and metabolic partitioning of α-linolenic acid are contingent on life stage in human CD3(+) T lymphocytes
por: West, Annette L., et al.
Publicado: (2022)

Oxylipin secretion by human CD3(+) T lymphocytes in vitro is modified by the exogenous essential fatty acid ratio and life stage
por: von Gerichten, Johanna, et al.
Publicado: (2023)

Genetically modified plants are an alternative to oily fish for providing n‐3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project
por: West, A. L., et al.
Publicado: (2020)

Progressive, Transgenerational Changes in Offspring Phenotype and Epigenotype following Nutritional Transition
por: Burdge, Graham C., et al.
Publicado: (2011)

Diet, Nutrition and Modulation of Genomic Expression in Fetal Origins of Adult Disease
por: Jackson, Alan A., et al.
Publicado: (2011)

Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study
por: Price, R. Jordan, et al.
Publicado: (2016)

Modification of subcutaneous white adipose tissue inflammation by omega-3 fatty acids is limited in human obesity-a double blind, randomised clinical trial
por: Fisk, Helena L, et al.
Publicado: (2022)

Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults
por: Rauschert, Sebastian, et al.
Publicado: (2020)

Vascular Dysfunction Induced in Offspring by Maternal Dietary Fat Involves Altered Arterial Polyunsaturated Fatty Acid Biosynthesis
por: Kelsall, Christopher J., et al.
Publicado: (2012)

Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes
por: West, Annette L., et al.
Publicado: (2020)

Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver()()()
por: Hoile, Samuel P., et al.
Publicado: (2013)

Epigenome‐wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS)
por: Antoun, Elie, et al.
Publicado: (2021)

Nausea and vomiting in early pregnancy: Effects on food intake and diet quality
por: Crozier, Sarah R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9919n5vjebvgqetfis5hbu4lkr