Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

Ataxin-7 (Atx7) is a disease-related protein associated with the pathogenesis of spinocerebellar ataxia 7, while its polyglutamine (polyQ) tract in N-terminus is the causative source of aggregation and proteinopathy. We investigated the structure, dynamics and aggregation properties of the N-termina...

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Detalles Bibliográficos
Autores principales: Hong, Jun-Ye, Wang, Dong-Dong, Xue, Wei, Yue, Hong-Wei, Yang, Hui, Jiang, Lei-Lei, Wang, Wen-Ning, Hu, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522498/
https://www.ncbi.nlm.nih.gov/pubmed/31097749
http://dx.doi.org/10.1038/s41598-019-43926-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522498/
https://www.ncbi.nlm.nih.gov/pubmed/31097749
http://dx.doi.org/10.1038/s41598-019-43926-9

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