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miR-23b-3p suppressing PGC1α promotes proliferation through reprogramming metabolism in osteosarcoma

Metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis is a hallmark of osteosarcoma (OS). However, the mechanisms of the metabolic switch have not been completely elucidated. Here we reported that the miR-23b-3p was significantly upregulated in OS cells. Functional studies suggested...

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Detalles Bibliográficos
Autores principales: Zhu, Ran, Li, Xinpan, Ma, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522531/
https://www.ncbi.nlm.nih.gov/pubmed/31097683
http://dx.doi.org/10.1038/s41419-019-1614-1