Environmental stress impairs photoreceptor outer segment (POS) phagocytosis and degradation and induces autofluorescent material accumulation in hiPSC-RPE cells

Retinal pigment epithelium (RPE) cell dysfunction is central to the pathogenesis of age-related macular degeneration (AMD), a leading cause of adult blindness. Aging, the single biggest risk factor for AMD development, favors increase in RPE autofluorescent material due to accumulation of POS-digest...

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Detalles Bibliográficos
Autores principales: Dalvi, Sonal, Galloway, Chad A., Winschel, Lauren, Hashim, Ali, Soto, Celia, Tang, Cynthia, MacDonald, Leslie A., Singh, Ruchira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522536/
https://www.ncbi.nlm.nih.gov/pubmed/31123602
http://dx.doi.org/10.1038/s41420-019-0171-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522536/
https://www.ncbi.nlm.nih.gov/pubmed/31123602
http://dx.doi.org/10.1038/s41420-019-0171-9

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