Optimal control nodes in disease-perturbed networks as targets for combination therapy

Most combination therapies are developed based on targets of existing drugs, which only represent a small portion of the human proteome. We introduce a network controllability-based method, OptiCon, for de novo identification of synergistic regulators as candidates for combination therapy. These reg...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Yuxuan, Chen, Chia-hui, Ding, Yang-yang, Wen, Xiao, Wang, Bingbo, Gao, Lin, Tan, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522545/
https://www.ncbi.nlm.nih.gov/pubmed/31097707
http://dx.doi.org/10.1038/s41467-019-10215-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522545/
https://www.ncbi.nlm.nih.gov/pubmed/31097707
http://dx.doi.org/10.1038/s41467-019-10215-y

Ejemplares similares