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LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation
Transforming growth factor β (TGFβ) is deposited in the extracellular space of diverse tissues. Resident fibroblasts respond to TGFβ and undergo myofibroblastic differentiation during tissue wound healing and cancer progression. Cancer-associated fibroblasts (CAFs) communicate with tumor cells durin...
Autores principales: | Morén, Anita, Bellomo, Claudia, Tsubakihara, Yutaro, Kardassis, Dimitris, Mikulits, Wolfgang, Heldin, Carl-Henrik, Moustakas, Aristidis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522550/ https://www.ncbi.nlm.nih.gov/pubmed/31097694 http://dx.doi.org/10.1038/s41389-019-0140-4 |
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