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Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

HIV-infected infants develop broadly neutralizing plasma responses with more rapid kinetics than adults, suggesting the ontogeny of infant responses could better inform a path to achievable vaccine targets. Here we reconstruct the developmental lineage of BF520.1, an infant-derived HIV-specific broa...

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Detalles Bibliográficos
Autores principales:	Simonich, Cassandra A., Doepker, Laura, Ralph, Duncan, Williams, James A., Dhar, Amrit, Yaffe, Zak, Gentles, Lauren, Small, Christopher T., Oliver, Brian, Vigdorovich, Vladimir, Mangala Prasad, Vidya, Nduati, Ruth, Sather, D. Noah, Lee, Kelly K., Matsen IV, Frederick A., Overbaugh, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522554/ https://www.ncbi.nlm.nih.gov/pubmed/31097697 http://dx.doi.org/10.1038/s41467-019-09481-7

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