Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance

Resistance to key first-line drugs is a major hurdle to achieve the global end tuberculosis (TB) targets. A prodrug, pyrazinamide (PZA) is the only drug, effective in latent TB, recommended in drug resistance and susceptible Mycobacterium tuberculosis (MTB) isolates. The prodrug conversion into acti...

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Detalles Bibliográficos
Autores principales: Khan, Muhammad Tahir, Khan, Abbas, Rehman, Ashfaq Ur, Wang, Yanjie, Akhtar, Khalid, Malik, Shaukat Iqbal, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522564/
https://www.ncbi.nlm.nih.gov/pubmed/31097767
http://dx.doi.org/10.1038/s41598-019-44013-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522564/
https://www.ncbi.nlm.nih.gov/pubmed/31097767
http://dx.doi.org/10.1038/s41598-019-44013-9

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