Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo

Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural microbial colonizer of the oral cavity. The challe...

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Detalles Bibliográficos
Autores principales: Darwish, Ghassan, Helmerhorst, Eva J., Schuppan, Detlef, Oppenheim, Frank G., Wei, Guoxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522598/
https://www.ncbi.nlm.nih.gov/pubmed/31097786
http://dx.doi.org/10.1038/s41598-019-43837-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522598/
https://www.ncbi.nlm.nih.gov/pubmed/31097786
http://dx.doi.org/10.1038/s41598-019-43837-9

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