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Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural microbial colonizer of the oral cavity. The challe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522598/ https://www.ncbi.nlm.nih.gov/pubmed/31097786 http://dx.doi.org/10.1038/s41598-019-43837-9 |