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Development of a stable chemically cross-linked erythropoietin dimer for use in the quality control of erythropoietin therapeutic products

Erythropoietin (EPO) is a glycoprotein hormone which promotes red cell replenishment and is also a global biotherapeutic medicine widely used to treat anaemia resulting, for example, from chemotherapy. Requirements of the European Pharmacopoeia stipulate that the level of dimer must be quantified in...

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Detalles Bibliográficos
Autores principales: Matejtschuk, Paul, Duru, Chinwe, Malik, Kiran P., Bristow, Adrian F., Costanzo, Angele, Burns, Chris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522647/
https://www.ncbi.nlm.nih.gov/pubmed/30972470
http://dx.doi.org/10.1007/s00216-019-01768-4