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PDK-1 mediated Hippo–YAP–IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells

Pyruvate dehydrogenase kinase-1 (PDK-1), a gatekeeper enzyme, was involved in cancer progression, such as tumor angiogenesis, cell survival, and growth. Recent evidence indicated that PDK-1 may be involved in lung cancer, however, the function and underlying mechanism of PDK-1 is remaining unclear....

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Detalles Bibliográficos
Autores principales: Wang, Guofang, Liu, Xiaomei, Xie, Jiali, Meng, Jinfei, Ni, Xiaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522739/
https://www.ncbi.nlm.nih.gov/pubmed/30988063
http://dx.doi.org/10.1042/BSR20182099