Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies

A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic activity. Synthesised compounds were tested against four hCAs (I, II, IX, and XII) revealing...

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Detalles Bibliográficos
Autores principales: Ammazzalorso, Alessandra, Carradori, Simone, Angeli, Andrea, Akdemir, Atilla, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522927/
https://www.ncbi.nlm.nih.gov/pubmed/31074307
http://dx.doi.org/10.1080/14756366.2019.1611801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522927/
https://www.ncbi.nlm.nih.gov/pubmed/31074307
http://dx.doi.org/10.1080/14756366.2019.1611801

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