Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors

In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in vitro antiproliferative activities against three cancer cell lines (MDA-MB-231, HeLa, and SMMC-7721). A number of...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Xiao-Yan, Chen, Hao, Li, Dong-Dong, Li, A-Liang, Wang, Wen-Yan, Gu, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522941/
https://www.ncbi.nlm.nih.gov/pubmed/31072147
http://dx.doi.org/10.1080/14756366.2019.1605364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522941/
https://www.ncbi.nlm.nih.gov/pubmed/31072147
http://dx.doi.org/10.1080/14756366.2019.1605364

Ejemplares similares