Cargando…

Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors

In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide, oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in vitro antiproliferative activities against three cancer cell lines (MDA-MB-231, HeLa, and SMMC-7721). A number of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Xiao-Yan, Chen, Hao, Li, Dong-Dong, Li, A-Liang, Wang, Wen-Yan, Gu, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522941/ https://www.ncbi.nlm.nih.gov/pubmed/31072147 http://dx.doi.org/10.1080/14756366.2019.1605364

Ejemplares similares

Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety
por: Bingul, Murat, et al.
Publicado: (2016)

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
por: Levent, Serkan, et al.
Publicado: (2017)

Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
por: El-Rayyes, Ali, et al.
Publicado: (2022)

Synthesis and Antibacterial Evaluation of New Sulfone Derivatives Containing 2-Aroxymethyl-1,3,4-Oxadiazole/Thiadiazole Moiety
por: Su, Shihu, et al.
Publicado: (2016)

Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
por: Özdemir, Ahmet, et al.
Publicado: (2017)

Biological activity of oxadiazole and thiadiazole derivatives
por: Atmaram, Upare Abhay, et al.
Publicado: (2022)

Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties
por: Szulczyk, Daniel, et al.
Publicado: (2017)

Synthesis and Bioactivity of Hydrazide-Hydrazones with the 1-Adamantyl-Carbonyl Moiety
por: Pham, Van Hien, et al.
Publicado: (2019)

Synthesis of Oxadiazoles, Thiadiazoles and Triazoles Derived from Benzo[b]thiophene.
por: Sharba, A. Hussain K., et al.
Publicado: (2005)

Design, Synthesis, and Anticancer Evaluation of Novel Indole Derivatives of Ursolic Acid as Potential Topoisomerase II Inhibitors
por: Li, A-Liang, et al.
Publicado: (2020)

A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies
por: Jabeen, Muafia, et al.
Publicado: (2018)

Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety
por: Popiołek, Łukasz, et al.
Publicado: (2017)

A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives
por: Zarafu, Irina, et al.
Publicado: (2020)

Corrigendum: Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies
por: Jabeen, Muafia, et al.
Publicado: (2018)

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety
por: Han, Xu, et al.
Publicado: (2020)

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions
por: Tokumaru, Kazuyuki, et al.
Publicado: (2017)

Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety
por: Shu, Yafei, et al.
Publicado: (2022)

Design, Synthesis, and Molecular Docking Study of Novel Heterocycles Incorporating 1,3,4-Thiadiazole Moiety as Potential Antimicrobial and Anticancer Agents
por: El-Naggar, Mohamed, et al.
Publicado: (2019)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Design, Synthesis, and Anticancer Activity Studies of Novel Quinoline-Chalcone Derivatives
por: Guan, Yong-Feng, et al.
Publicado: (2021)

Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones
por: Han, M. İhsan, et al.
Publicado: (2023)

Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis
por: Thayer, Mai B., et al.
Publicado: (2021)

Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoromethylpyrazoyl moiety
por: Shi, Hai-Bo, et al.
Publicado: (2022)

Insect growth regulators with hydrazide moiety inhibit strigolactone biosynthesis in rice
por: Kawada, Kojiro, et al.
Publicado: (2022)

Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents
por: Zampieri, Daniele, et al.
Publicado: (2022)

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
por: Baburajeev, C. P., et al.
Publicado: (2017)

Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues
por: Noureldin, Nada A., et al.
Publicado: (2021)

2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential
por: Kumar, Davinder, et al.
Publicado: (2023)

Thiadiazole derivatives as anticancer agents
por: Szeliga, Monika
Publicado: (2020)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties
por: Xu, Weiming, et al.
Publicado: (2011)

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
por: Nedopekina, Darya A., et al.
Publicado: (2017)

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus
por: Dyniewicz, Jolanta, et al.
Publicado: (2020)

Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety
por: Ugwu, David Izuchukwu, et al.
Publicado: (2018)

Synthesis and Evaluation of the Anti-Microbial Activity of New Heterocycles Containing the 1,3,4-Thiadiazole Moiety
por: Farghaly, Thoraya A., et al.
Publicado: (2011)

Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies
por: Alam, Mohammad Mahboob, et al.
Publicado: (2020)

Synthesis and Antibacterial Evaluation of Novel 1,3,4-Oxadiazole Derivatives Containing Sulfonate/Carboxylate Moiety
por: Wang, Lei, et al.
Publicado: (2020)

Design, Synthesis, and Biological Activity of Novel Chalcone Derivatives Containing an 1,2,4-Oxadiazole Moiety
por: Luo, Ling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iinfp0i46mpnqui7jklip4oohb