Novel sulphonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers

A series of sulphonamide benzoquinazolinones 5–18 was synthesized and evaluated for cytotoxic activity against MDA-MB-231 cell line. The compounds showed IC(50) ranging from 0.26 to 161.49 µM. The promising compounds were evaluated for their inhibitory profile against epidermal growth factor (EGFR)...

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Detalles Bibliográficos
Autores principales: Soliman, Aiten M., Alqahtani, Ali S., Ghorab, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522976/
https://www.ncbi.nlm.nih.gov/pubmed/31074303
http://dx.doi.org/10.1080/14756366.2019.1609469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522976/
https://www.ncbi.nlm.nih.gov/pubmed/31074303
http://dx.doi.org/10.1080/14756366.2019.1609469

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