Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleoti...

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Detalles Bibliográficos
Autores principales: Lucafò, Marianna, Stocco, Gabriele, Martelossi, Stefano, Favretto, Diego, Franca, Raffaella, Malusà, Noelia, Lora, Angela, Bramuzzo, Matteo, Naviglio, Samuele, Cecchin, Erika, Toffoli, Giuseppe, Ventura, Alessandro, Decorti, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523194/
https://www.ncbi.nlm.nih.gov/pubmed/30987408
http://dx.doi.org/10.3390/genes10040277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523194/
https://www.ncbi.nlm.nih.gov/pubmed/30987408
http://dx.doi.org/10.3390/genes10040277

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