IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2). The latter is activated by drugs and endogenous...

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Detalles Bibliográficos
Autores principales: Wang, Zhao, Guhl, Sven, Franke, Kristin, Artuc, Metin, Zuberbier, Torsten, Babina, Magda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523246/
https://www.ncbi.nlm.nih.gov/pubmed/30979016
http://dx.doi.org/10.3390/cells8040341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523246/
https://www.ncbi.nlm.nih.gov/pubmed/30979016
http://dx.doi.org/10.3390/cells8040341

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