Cargando…

Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer

The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer activation was ascertained. However, many years of structure determination has shown that EGFR is not completely un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin-Fernandez, Marisa L., Clarke, David T., Roberts, Selene K., Zanetti-Domingues, Laura C., Gervasio, Francesco L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523254/ https://www.ncbi.nlm.nih.gov/pubmed/30959819 http://dx.doi.org/10.3390/cells8040316

Ejemplares similares

Structural basis of the effect of activating mutations on the EGF receptor
por: Galdadas, Ioannis, et al.
Publicado: (2021)

Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
por: Jacot, W, et al.
Publicado: (2004)

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
por: Zanetti-Domingues, Laura C., et al.
Publicado: (2018)

Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells
por: Yoshie, Mikihiro, et al.
Publicado: (2023)

The Position of EGF Deprivation in the Management of Advanced Non-Small Cell Lung Cancer
por: Crombet Ramos, Tania, et al.
Publicado: (2021)

Targeting the EGF receptor family in non-small cell lung cancer—increased complexity and future perspectives
por: Boch, Tobias, et al.
Publicado: (2022)

Steered molecular dynamic simulations reveal Marfan syndrome mutations disrupt fibrillin-1 cbEGF domain mechanosensitive calcium binding
por: Haller, Stephen J., et al.
Publicado: (2020)

PET imaging of patients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer
por: Memon, A A, et al.
Publicado: (2011)

Systems Analysis of EGF Receptor Signaling Dynamics with Micro-Western Arrays
por: Ciaccio, Mark F., et al.
Publicado: (2010)

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
por: Liu, Ning Sheng, et al.
Publicado: (2009)

Importance of the Force Field Choice in Capturing Functionally Relevant Dynamics in the von Willebrand Factor
por: Kuzmanic, Antonija, et al.
Publicado: (2019)

Local signaling by the EGF receptor
por: Kempiak, Stephan J., et al.
Publicado: (2003)

Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular Vesicles
por: Zanetti-Domingues, Laura C., et al.
Publicado: (2020)

Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival.
por: Dazzi, H., et al.
Publicado: (1989)

Identifying predictive biomarkers of CIMAvaxEGF success in non–small cell lung cancer patients
por: Lorenzo-Luaces, Patricia, et al.
Publicado: (2020)

Epidermal growth factor (EGF) promotes phosphorylation at threonine-654 of the EGF receptor: possible role of protein kinase C in homologous regulation of the EGF receptor
Publicado: (1986)

The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants
por: Chung, Byung Min, et al.
Publicado: (2009)

A Systematic Investigation of Differential Effects of Cell Culture Substrates on the Extent of Artifacts in Single-Molecule Tracking
por: Zanetti-Domingues, Laura C., et al.
Publicado: (2012)

Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity
Publicado: (1992)

Effect of blockade of the EGF system on wound healing in patients vaccinated with CIMAvax® EGF
por: Fernández Lorente, Aymara, et al.
Publicado: (2013)

Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedule
por: Popa, Xitlally, et al.
Publicado: (2020)

A small molecule inhibitor of HER3: a proof-of-concept study
por: Colomba, Audrey, et al.
Publicado: (2020)

CIMAvax-EGF: A New Therapeutic Vaccine for Advanced Non-Small Cell Lung Cancer Patients
por: Saavedra, Danay, et al.
Publicado: (2017)

Expression of epidermal growth factor receptor (EGF-R) in human lung tumours.
por: Cerny, T., et al.
Publicado: (1986)

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes
Publicado: (1996)

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
por: Swindle, C. Scott, et al.
Publicado: (2001)

The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus
por: Korotkevych, Nataliia V., et al.
Publicado: (2015)

The EGF receptor is an actin-binding protein
Publicado: (1992)

EGF receptor ligands: recent advances
por: Singh, Bhuminder, et al.
Publicado: (2016)

EGF receptor modulates HEV entry in human hepatocytes
por: Schrader, Jil A., et al.
Publicado: (2023)

Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
por: Akslen, L. A., et al.
Publicado: (1993)

Hydrophobic Fluorescent Probes Introduce Artifacts into Single Molecule Tracking Experiments Due to Non-Specific Binding
por: Zanetti-Domingues, Laura C., et al.
Publicado: (2013)

EGF receptor lysosomal degradation is delayed in the cells stimulated with EGF-Quantum dot bioconjugate but earlier key events of endocytic degradative pathway are similar to that of native EGF
por: Salova, Anna V., et al.
Publicado: (2017)

Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors.
por: Kwok, T. T., et al.
Publicado: (1991)

JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor
por: Zhang, Fu-quan, et al.
Publicado: (2015)

The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations
por: Kalli, Antreas C., et al.
Publicado: (2016)

Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer
por: Martin-Fernandez, Marisa L.
Publicado: (2022)

An ultrasensitive sorting mechanism for EGF Receptor Endocytosis
por: Schmidt-Glenewinkel, Hannah, et al.
Publicado: (2008)

The interactome of human EGF/ErbB receptors
por: Uetz, Peter, et al.
Publicado: (2006)

Targeting the EGF Receptor for Ovarian Cancer Therapy
por: Zeineldin, Reema, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_s49a8u0ksgihm0gv13r6h0g4e1