Synthesis and Biological Evaluation of RGD–Cryptophycin Conjugates for Targeted Drug Delivery

Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52 failed as a clinical candidate in cancer treatmen...

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Detalles Bibliográficos
Autores principales: Borbély, Adina, Figueras, Eduard, Martins, Ana, Esposito, Simone, Auciello, Giulio, Monteagudo, Edith, Di Marco, Annalise, Summa, Vincenzo, Cordella, Paola, Perego, Raffaella, Kemker, Isabell, Frese, Marcel, Gallinari, Paola, Steinkühler, Christian, Sewald, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523311/
https://www.ncbi.nlm.nih.gov/pubmed/30939768
http://dx.doi.org/10.3390/pharmaceutics11040151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523311/
https://www.ncbi.nlm.nih.gov/pubmed/30939768
http://dx.doi.org/10.3390/pharmaceutics11040151

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