Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9

Enhanced S-cone syndrome (ESCS) is caused by recessive mutations in the photoreceptor cell transcription factor NR2E3. Loss of NR2E3 is characterized by repression of rod photoreceptor cell gene expression, over-expansion of the S-cone photoreceptor cell population, and varying degrees of M- and L-c...

Descripción completa

Detalles Bibliográficos
Autores principales: Bohrer, Laura R., Wiley, Luke A., Burnight, Erin R., Cooke, Jessica A., Giacalone, Joseph C., Anfinson, Kristin R., Andorf, Jeaneen L., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523438/
https://www.ncbi.nlm.nih.gov/pubmed/30959774
http://dx.doi.org/10.3390/genes10040278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523438/
https://www.ncbi.nlm.nih.gov/pubmed/30959774
http://dx.doi.org/10.3390/genes10040278

Ejemplares similares