Cargando…

Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds

Tumorigenesis in humans is a multistep progression that imitates genetic changes leading to cell transformation and malignancy. Oncogenic kinases play a central role in cancer progression, rendering them putative targets for the design of anti-cancer drugs. The presented work aims to identify the po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ikram, Nazia, Mirza, Muhammad Usman, Vanmeert, Michiel, Froeyen, Matheus, Salo-Ahen, Outi M. H., Tahir, Muhammad, Qazi, Aamer, Ahmad, Sarfraz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523505/ https://www.ncbi.nlm.nih.gov/pubmed/30925835 http://dx.doi.org/10.3390/biom9040124

Ejemplares similares

Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

Corrigendum to ‘Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach’ [European Journal of Pharmaceutical Sciences 155 (2020) 105537]
por: Mirza, Muhammad Usman, et al.
Publicado: (2021)

In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors
por: Mirza, Muhammad Usman, et al.
Publicado: (2019)

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins
por: Usman Mirza, Muhammad, et al.
Publicado: (2016)

Erratum: Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins
por: Mirza, Muhammad Usman, et al.
Publicado: (2017)

Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

Antigenic Peptide Prediction From E6 and E7 Oncoproteins of HPV Types 16 and 18 for Therapeutic Vaccine Design Using Immunoinformatics and MD Simulation Analysis
por: Jabbar, Basit, et al.
Publicado: (2018)

Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity
por: Ahmad, Sarfraz, et al.
Publicado: (2019)

In Vitro Antidiabetic, Anti-Obesity and Antioxidant Analysis of Ocimum basilicum Aerial Biomass and in Silico Molecular Docking Simulations with Alpha-Amylase and Lipase Enzymes
por: Noor, Zoy I, et al.
Publicado: (2019)

A novel pathogenic missense variant in CNNM4 underlying Jalili syndrome: Insights from molecular dynamics simulations
por: Parveen, Asia, et al.
Publicado: (2019)

Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from Pteris cretica L.
por: Saleem, Farooq, et al.
Publicado: (2019)

Toxicity Evaluation of the Naphthalen-2-yl 3,5-Dinitrobenzoate: A Drug Candidate for Alzheimer Disease
por: Anwar, Fareeha, et al.
Publicado: (2021)

Integrated Computational Approach for Virtual Hit Identification against Ebola Viral Proteins VP35 and VP40
por: Mirza, Muhammad Usman, et al.
Publicado: (2016)

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins
por: Vanmeert, Michiel, et al.
Publicado: (2019)

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins
por: Vanmeert, Michiel, et al.
Publicado: (2019)

Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches
por: Alamri, Mubarak A., et al.
Publicado: (2020)

Market violence through destructive entrepreneurship: Assessing institutional responses to the proliferation of counterfeit traditional and alternative medicines in Ghana
por: Ahen, Frederick, et al.
Publicado: (2023)

A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach
por: Rehman, Hafiz Muzzammel, et al.
Publicado: (2020)

Identification of HPr kinase/phosphorylase inhibitors: novel antimicrobials against resistant Enterococcus faecalis
por: Kumar, Sandeep, et al.
Publicado: (2022)

Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation
por: Maher, Saima, et al.
Publicado: (2020)

High-Throughput Molecular Dynamics-Based Alchemical Free Energy Calculations for Predicting the Binding Free Energy Change Associated with the Selected Omicron Mutations in the Spike Receptor-Binding Domain of SARS-CoV-2
por: Bhadane, Rajendra, et al.
Publicado: (2022)

Folate Conjugated Polyethylene Glycol Probe for Tumor-Targeted Drug Delivery of 5-Fluorouracil
por: Sarwar, Shabnam, et al.
Publicado: (2022)

Molecular Modeling in Drug Design
por: Wade, Rebecca C., et al.
Publicado: (2019)

Effect of Berberis vulgaris L. root extract on ifosfamide-induced in vivo toxicity and in vitro cytotoxicity
por: Ilyas, Shazia, et al.
Publicado: (2021)

Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in Escherichia coli: Insights from Molecular Dynamics Simulations
por: Durrani, Faiza Gul, et al.
Publicado: (2019)

Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine
por: Aalto, Anna L., et al.
Publicado: (2023)

Dock-able linear and homodetic di, tri, tetra and pentapeptide library from canonical amino acids: SARS-CoV-2 Mpro as a case study
por: Ahmad, Sarfraz, et al.
Publicado: (2023)

A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo
por: Naudin, Clément, et al.
Publicado: (2017)

Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors
por: Mirza, Muhammad Usman, et al.
Publicado: (2015)

Enhanced Thermostability and Enzymatic Activity of cel6A Variants from Thermobifida fusca by Empirical Domain Engineering
por: Ali, Imran, et al.
Publicado: (2020)

NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases
por: Denesyuk, Alexander I., et al.
Publicado: (2020)

Negative impact of the COVID-19 pandemic on routine childhood immunization: experience from Pakistan
por: Rana, Muhammad Suleman, et al.
Publicado: (2021)

Overlapping clinical manifestations of COVID-19 with endemic infectious diseases in Pakistan: A looming threat of multiple lethal combinations
por: Rana, Muhammad Suleman, et al.
Publicado: (2021)

Chikungunya virus: Molecular epidemiology of nonstructural proteins in Pakistan
por: Badar, Nazish, et al.
Publicado: (2021)

Epidemiological trend of chikungunya outbreak in Pakistan: 2016–2018
por: Badar, Nazish, et al.
Publicado: (2019)

Potential Anticancer Properties and Mechanisms of Action of Formononetin
por: Jiang, Dongjun, et al.
Publicado: (2019)

Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
por: Iqbal, Zafar, et al.
Publicado: (2020)

Prevention and control of coronavirus epidemic: role of clinical awareness and flow of accurate information
por: RANA, MUHAMMAD SULEMAN, et al.
Publicado: (2021)

Impact of previous SARS-CoV-2 infection on the rate of mortality in dengue. A preliminary report from Pakistan
por: Rana, Muhammad Suleman, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rtecesfd0q738m5n8m0r1pkt1e