CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

Sanitization of nucleotide pools is essential for genome maintenance. Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) is a key enzyme in this pathway since it catalyzes the cleavage of 2′-deoxyuridine 5′-triphosphate (dUTP) into 2′-deoxyuridine 5′-monophosphate (dUMP) and inorganic pyroph...

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Detalles Bibliográficos
Autores principales: Pálinkás, Hajnalka Laura, Rácz, Gergely Attila, Gál, Zoltán, Hoffmann, Orsolya Ivett, Tihanyi, Gergely, Róna, Gergely, Gócza, Elen, Hiripi, László, Vértessy, Beáta G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523736/
https://www.ncbi.nlm.nih.gov/pubmed/30987342
http://dx.doi.org/10.3390/biom9040136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523736/
https://www.ncbi.nlm.nih.gov/pubmed/30987342
http://dx.doi.org/10.3390/biom9040136

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