Promoter Hypermethylation of Tumor-Suppressor Genes p16(INK4a), RASSF1A, TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers

Silencing of tumor-suppressor genes (TSGs) by DNA promoter hypermethylation is an early event in carcinogenesis; hence, TSGs may serve as early tumor biomarkers. We determined the promoter methylation levels of p16(INK4a), RASSF1A, TIMP3, and PCQAP/MED15 TSGs in salivary DNA from oral cancer (OC) an...

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Detalles Bibliográficos
Autores principales: Liyanage, Chamikara, Wathupola, Asanga, Muraleetharan, Sanjayan, Perera, Kanthi, Punyadeera, Chamindie, Udagama, Preethi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523930/
https://www.ncbi.nlm.nih.gov/pubmed/31013839
http://dx.doi.org/10.3390/biom9040148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523930/
https://www.ncbi.nlm.nih.gov/pubmed/31013839
http://dx.doi.org/10.3390/biom9040148

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