Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

BACKGROUND: Most clinical trials with time-to-event primary outcomes are designed assuming constant event rates and proportional hazards over time. Non-constant event rates and non-proportional hazards are seen increasingly frequently in trials. The objectives of this review were firstly to identify...

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Detalles Bibliográficos
Autores principales: Jachno, Kim, Heritier, Stephane, Wolfe, Rory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524252/
https://www.ncbi.nlm.nih.gov/pubmed/31096924
http://dx.doi.org/10.1186/s12874-019-0749-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524252/
https://www.ncbi.nlm.nih.gov/pubmed/31096924
http://dx.doi.org/10.1186/s12874-019-0749-1

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