MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia

BACKGROUND: Acute myeloid leukemia (AML) is initiated and maintained by a unique, small subset of leukemia stem cells (LSCs). LSCs are characterized by unrestricted self-renewal and contribute to the malignancy of leukemia. Aberrant protein fucosylation is associated with AML progression. However, i...

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Detalles Bibliográficos
Autores principales: Liu, Bing, Ma, Hongye, Liu, Qianqian, Xiao, Yang, Pan, Shimeng, Zhou, Huimin, Jia, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524323/
https://www.ncbi.nlm.nih.gov/pubmed/31097000
http://dx.doi.org/10.1186/s13046-019-1179-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524323/
https://www.ncbi.nlm.nih.gov/pubmed/31097000
http://dx.doi.org/10.1186/s13046-019-1179-y

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