Brønsted acid and Pd–PHOX dual-catalysed enantioselective addition of activated C-pronucleophiles to internal dienes

We describe the development of Pd–PHOX-catalysed enantioselective couplings of internal dienes with malononitrile and other activated C-pronucleophiles. Reactions are dramatically accelerated by the addition of Et(3)N·HBAr(F)(4) as a Brønsted acid co-catalyst, enabling a suite of products bearing a...

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Detalles Bibliográficos
Autores principales: Park, Sangjune, Adamson, Nathan J., Malcolmson, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524568/
https://www.ncbi.nlm.nih.gov/pubmed/31183071
http://dx.doi.org/10.1039/c9sc00633h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524568/
https://www.ncbi.nlm.nih.gov/pubmed/31183071
http://dx.doi.org/10.1039/c9sc00633h

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