Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

BACKGROUND: The amide derivatives of nonsteroidal anti-inflammatory drugs have been reported to possess antitumor activity. The present work describes the synthesis of dexibuprofen amide analogues (4a–j) as potential anticancer agents. METHODS: The title amides (4a–j) were obtained by simple nucleop...

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Detalles Bibliográficos
Autores principales: Ashraf, Zaman, Mahmood, Tariq, Hassan, Mubashir, Afzal, Samina, Rafique, Hummera, Afzal, Khurram, Latip, Jalifah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524612/
https://www.ncbi.nlm.nih.gov/pubmed/31190743
http://dx.doi.org/10.2147/DDDT.S178595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524612/
https://www.ncbi.nlm.nih.gov/pubmed/31190743
http://dx.doi.org/10.2147/DDDT.S178595

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