Cargando…

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation

BACKGROUND: The amide derivatives of nonsteroidal anti-inflammatory drugs have been reported to possess antitumor activity. The present work describes the synthesis of dexibuprofen amide analogues (4a–j) as potential anticancer agents. METHODS: The title amides (4a–j) were obtained by simple nucleop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ashraf, Zaman, Mahmood, Tariq, Hassan, Mubashir, Afzal, Samina, Rafique, Hummera, Afzal, Khurram, Latip, Jalifah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524612/ https://www.ncbi.nlm.nih.gov/pubmed/31190743 http://dx.doi.org/10.2147/DDDT.S178595

Ejemplares similares

Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs
por: Ashraf, Zaman, et al.
Publicado: (2016)

Carvacrol derivatives as mushroom tyrosinase inhibitors; synthesis, kinetics mechanism and molecular docking studies
por: Ashraf, Zaman, et al.
Publicado: (2017)

Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives
por: Rafiq, Muhammad, et al.
Publicado: (2019)

Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors
por: Rashid, Muhammad, et al.
Publicado: (2020)

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis
por: Nazir, Yasir, et al.
Publicado: (2022)

Dexibuprofen nanocrystals with improved therapeutic performance: fabrication, characterization, in silico modeling, and in vivo evaluation
por: Ullah, Naseem, et al.
Publicado: (2018)

Sulfonamide-Based Azaheterocyclic Schiff Base Derivatives as Potential Carbonic Anhydrase Inhibitors: Synthesis, Cytotoxicity, and Enzyme Inhibitory Kinetics
por: Abas, Mujahid, et al.
Publicado: (2020)

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking
por: González-Cofrade, Laura, et al.
Publicado: (2022)

Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agents
por: Hoang, Ngo Xuan, et al.
Publicado: (2020)

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches
por: Aqeel, Muhammad Tahir, et al.
Publicado: (2018)

Dexibuprofen Therapeutic Advances: Prodrugs and Nanotechnological Formulations
por: Gliszczyńska, Anna, et al.
Publicado: (2021)

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking
por: Yıldırım, Hatice, et al.
Publicado: (2022)

Methyl 3,5-dibromo-4-methylbenzoate
por: Saeed, Aamer, et al.
Publicado: (2010)

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
por: Danne, Ashruba B., et al.
Publicado: (2021)

Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies
por: Abbas, Qamar, et al.
Publicado: (2017)

Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic rector
por: Khan, Jahangir, et al.
Publicado: (2018)

Microwave-assisted synthesis and bioevaluation of new sulfonamides
por: Gul, Halise Inci, et al.
Publicado: (2017)

Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations
por: Muralidharan, Selvadurai
Publicado: (2012)

Novel Strategies against Cancer: Dexibuprofen-Loaded Nanostructured Lipid Carriers
por: Thiruchenthooran, Vaikunthavasan, et al.
Publicado: (2022)

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies
por: Sahu, Nawal Kishore, et al.
Publicado: (2023)

Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, in silico and preliminary kinetic studies
por: Elgazar, Abdullah A., et al.
Publicado: (2023)

High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
por: Afzal, Sameen, et al.
Publicado: (2017)

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents
por: Krzywik, Julia, et al.
Publicado: (2020)

Antioxidant, Acetylcholinesterase, Butyrylcholinesterase, and α-glucosidase Inhibitory Activities of Corchorus depressus
por: Afzal, Samina, et al.
Publicado: (2017)

Design, Syntheses, and Bioevaluations of Some Novel N(2)-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents
por: Lakhani, Kinjal, et al.
Publicado: (2021)

Thiazole–Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation
por: Kasetti, Ashok Babu, et al.
Publicado: (2021)

Development and Validation of a HPLC and an UV Spectrophotometric Methods for Determination of Dexibuprofen in Pharmaceutical Preparations
por: Muralidharan, Selvadurai, et al.
Publicado: (2011)

Enhanced Solubility and Biological Activity of Dexibuprofen-Loaded Silica-Based Ternary Solid Dispersions
por: Asim, Muhammad, et al.
Publicado: (2023)

Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
por: Liu, Zhiqian, et al.
Publicado: (2014)

Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids †
por: Colín-Lozano, Blanca, et al.
Publicado: (2018)

Immunomodulatory, Cytotoxicity, and Antioxidant Activities of Roots of Ziziphus mauritiana
por: Afzal, Samina, et al.
Publicado: (2017)

Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics
por: Nazir, Yasir, et al.
Publicado: (2021)

Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery
por: Ali, Fatima Ramzan, et al.
Publicado: (2017)

Dexibuprofen Biodegradable Nanoparticles: One Step Closer towards a Better Ocular Interaction Study
por: Sánchez-López, Elena, et al.
Publicado: (2020)

An Electrochemical DNA Biosensor for Carcinogenicity of Anticancer Compounds Based on Competition between Methylene Blue and Oligonucleotides
por: Md. Sani, Nor Diyana, et al.
Publicado: (2019)

Synthesis, Bioevaluation, Structure-Activity Relationship and Docking Studies of Natural Product Inspired (Z)-3-benzylideneisobenzofuran-1(3H)-ones as Highly Potent antioxidants and Antiplatelet agents
por: Shyamlal, Bharti Rajesh Kumar, et al.
Publicado: (2020)

Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
por: Derita, Marcos, et al.
Publicado: (2013)

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies
por: Huneif, Mohammed A., et al.
Publicado: (2023)

Repurposing anti-inflammatory drugs for fighting planktonic and biofilm growth. New carbazole derivatives based on the NSAID carprofen: synthesis, in silico and in vitro bioevaluation
por: Dumitrascu, Florea, et al.
Publicado: (2023)

Screening of Pathogenic Missense Single Nucleotide Variants From LHPP Gene Associated With the Hepatocellular Carcinoma: An In silico Approach
por: Mahmood, Malik Siddique, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_241hkhvj7fsabbsqtonoi8s87f