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De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency
CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methy...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524733/ https://www.ncbi.nlm.nih.gov/pubmed/31056481 http://dx.doi.org/10.1016/j.stemcr.2019.04.008 |