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De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methy...

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Detalles Bibliográficos
Autores principales: Yagi, Masaki, Kabata, Mio, Ukai, Tomoyo, Ohta, Sho, Tanaka, Akito, Shimada, Yui, Sugimoto, Michihiko, Araki, Kimi, Okita, Keisuke, Woltjen, Knut, Hochedlinger, Konrad, Yamamoto, Takuya, Yamada, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524733/
https://www.ncbi.nlm.nih.gov/pubmed/31056481
http://dx.doi.org/10.1016/j.stemcr.2019.04.008