Mechanistic Basis for the Differential Effects of Rivaroxaban and Apixaban on Global Tests of Coagulation

Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time. To investigate this phenomenon, we used a factor Xa-directed substrate in a buffer system. A...

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Detalles Bibliográficos
Autores principales: Kim, Paul Y., Yeh, Calvin H., Dale, Brian J., Leslie, Beverly A., Stafford, Alan R., Fredenburgh, James C., Hirsh, Jack, Weitz, Jeffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524873/
https://www.ncbi.nlm.nih.gov/pubmed/31249942
http://dx.doi.org/10.1055/s-0038-1649507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524873/
https://www.ncbi.nlm.nih.gov/pubmed/31249942
http://dx.doi.org/10.1055/s-0038-1649507

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