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Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review

Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von Willebrand factor (VWF) multimers and (2) as an...

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Autores principales: van der Vorm, Lisa N., Remijn, Jasper A., de Laat, Bas, Huskens, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524877/
https://www.ncbi.nlm.nih.gov/pubmed/31249945
http://dx.doi.org/10.1055/s-0038-1660505
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author van der Vorm, Lisa N.
Remijn, Jasper A.
de Laat, Bas
Huskens, Dana
author_facet van der Vorm, Lisa N.
Remijn, Jasper A.
de Laat, Bas
Huskens, Dana
author_sort van der Vorm, Lisa N.
collection PubMed
description Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von Willebrand factor (VWF) multimers and (2) as an activator of platelets. Although the molecular mechanisms of fibrinolysis are well defined, insights on the effects of plasmin on VWF and platelets are relatively scarce and sometimes conflicting. Hence, this review provides an overview of the literature on the effects of plasmin on VWF multimeric structures, on VWF binding to platelets, and on platelet activation. This information is placed in the context of possible applications of thrombolytic therapy for the condition thrombotic thrombocytopenic purpura.
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spelling pubmed-65248772019-06-27 Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review van der Vorm, Lisa N. Remijn, Jasper A. de Laat, Bas Huskens, Dana TH Open Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von Willebrand factor (VWF) multimers and (2) as an activator of platelets. Although the molecular mechanisms of fibrinolysis are well defined, insights on the effects of plasmin on VWF and platelets are relatively scarce and sometimes conflicting. Hence, this review provides an overview of the literature on the effects of plasmin on VWF multimeric structures, on VWF binding to platelets, and on platelet activation. This information is placed in the context of possible applications of thrombolytic therapy for the condition thrombotic thrombocytopenic purpura. Georg Thieme Verlag KG 2018-06-07 /pmc/articles/PMC6524877/ /pubmed/31249945 http://dx.doi.org/10.1055/s-0038-1660505 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle van der Vorm, Lisa N.
Remijn, Jasper A.
de Laat, Bas
Huskens, Dana
Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title_full Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title_fullStr Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title_full_unstemmed Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title_short Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
title_sort effects of plasmin on von willebrand factor and platelets: a narrative review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524877/
https://www.ncbi.nlm.nih.gov/pubmed/31249945
http://dx.doi.org/10.1055/s-0038-1660505
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