Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related diseases, as well as therapeutic approaches, the tech...

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Detalles Bibliográficos
Autores principales: Herdy, Joseph, Schafer, Simon, Kim, Yongsung, Ansari, Zoya, Zangwill, Dina, Ku, Manching, Paquola, Apua, Lee, Hyungjun, Mertens, Jerome, Gage, Fred H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Stem Cells and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524968/
https://www.ncbi.nlm.nih.gov/pubmed/31099332
http://dx.doi.org/10.7554/eLife.41356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524968/
https://www.ncbi.nlm.nih.gov/pubmed/31099332
http://dx.doi.org/10.7554/eLife.41356

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