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Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons
Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related diseases, as well as therapeutic approaches, the tech...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524968/ https://www.ncbi.nlm.nih.gov/pubmed/31099332 http://dx.doi.org/10.7554/eLife.41356 |