Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes

Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower template unwinding following helicase–polymerase uncoupling and establishment of prolonged stalled fork structures. Fork slowing and stalling oc...

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Detalles Bibliográficos
Autores principales: Taylor, Martin R.G., Yeeles, Joseph T.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525111/
https://www.ncbi.nlm.nih.gov/pubmed/30894292
http://dx.doi.org/10.1016/j.jmb.2019.03.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525111/
https://www.ncbi.nlm.nih.gov/pubmed/30894292
http://dx.doi.org/10.1016/j.jmb.2019.03.011

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