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Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes
Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower template unwinding following helicase–polymerase uncoupling and establishment of prolonged stalled fork structures. Fork slowing and stalling oc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525111/ https://www.ncbi.nlm.nih.gov/pubmed/30894292 http://dx.doi.org/10.1016/j.jmb.2019.03.011 |