Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human embryonic stem cells (ESCs) to END offers a tractable syste...

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Detalles Bibliográficos
Autores principales: Genga, Ryan M.J., Kernfeld, Eric M., Parsi, Krishna M., Parsons, Teagan J., Ziller, Michael J., Maehr, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525305/
https://www.ncbi.nlm.nih.gov/pubmed/30995470
http://dx.doi.org/10.1016/j.celrep.2019.03.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525305/
https://www.ncbi.nlm.nih.gov/pubmed/30995470
http://dx.doi.org/10.1016/j.celrep.2019.03.076

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