A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

BACKGROUND: Adenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination o...

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Detalles Bibliográficos
Autores principales: Bertke, Michelle M., Dubiak, Kyle M., Cronin, Laura, Zeng, Erliang, Huber, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525467/
https://www.ncbi.nlm.nih.gov/pubmed/31101013
http://dx.doi.org/10.1186/s12864-019-5773-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525467/
https://www.ncbi.nlm.nih.gov/pubmed/31101013
http://dx.doi.org/10.1186/s12864-019-5773-3

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