Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

BACKGROUND: Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of pro-inflammatory cytokines has been proposed based on in vivo and primary culture studies. However, mechanisms are hard to study in vivo as sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheppard, Olivia, Coleman, Michael P., Durrant, Claire S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525970/
https://www.ncbi.nlm.nih.gov/pubmed/31103036
http://dx.doi.org/10.1186/s12974-019-1490-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525970/
https://www.ncbi.nlm.nih.gov/pubmed/31103036
http://dx.doi.org/10.1186/s12974-019-1490-8

Ejemplares similares