Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice

Chronic over-nutrition promotes adipocyte hypertrophy that creates inflammatory milieu leading to macrophage infiltration and their phenotypic switching during obesity. The SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1) has been identified as an important player in inflammatory disease...

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Detalles Bibliográficos
Autores principales: Sharma, Yadhu, Ahmad, Altaf, Yavvari, Prabhu Srinivas, Kumar Muwal, Sandeep, Bajaj, Avinash, Khan, Farah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526246/
https://www.ncbi.nlm.nih.gov/pubmed/31108319
http://dx.doi.org/10.1016/j.omtn.2019.04.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526246/
https://www.ncbi.nlm.nih.gov/pubmed/31108319
http://dx.doi.org/10.1016/j.omtn.2019.04.020

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