Cargando…

Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice

Chronic over-nutrition promotes adipocyte hypertrophy that creates inflammatory milieu leading to macrophage infiltration and their phenotypic switching during obesity. The SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1) has been identified as an important player in inflammatory disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Yadhu, Ahmad, Altaf, Yavvari, Prabhu Srinivas, Kumar Muwal, Sandeep, Bajaj, Avinash, Khan, Farah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526246/ https://www.ncbi.nlm.nih.gov/pubmed/31108319 http://dx.doi.org/10.1016/j.omtn.2019.04.020

Ejemplares similares

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
por: Christophi, George P., et al.
Publicado: (2009)

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism
por: Pal, Sanjay, et al.
Publicado: (2019)

Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice
por: Kim, Jongkil, et al.
Publicado: (2016)

Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling
por: Sun, Ziying, et al.
Publicado: (2022)

An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload
por: Ameka, Magdalene K., et al.
Publicado: (2022)

A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response
por: Kar, Animesh, et al.
Publicado: (2023)

Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML
por: Zhao, Yuming, et al.
Publicado: (2023)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10
por: Xiao, Peng, et al.
Publicado: (2019)

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity
por: Myers, Darienne R., et al.
Publicado: (2020)

Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
por: Jopling, Chris, et al.
Publicado: (2007)

Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells
por: Chatterjee, Sushmita, et al.
Publicado: (2023)

Proinflammatory Phenotype and Increased Caveolin-1 in Alveolar Macrophages with Silenced CFTR mRNA
por: Xu, Yaqin, et al.
Publicado: (2010)

Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages
por: Du, Li, et al.
Publicado: (2023)

Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
por: Hong, Shiao-Ya, et al.
Publicado: (2023)

Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation
por: Bashir, Samina, et al.
Publicado: (2019)

Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner
por: Abbasi, Mojdeh, et al.
Publicado: (2021)

Functions of Shp2 in cancer
por: Zhang, Jie, et al.
Publicado: (2015)

Sidestepping SHP2 inhibition
por: Popescu, Bogdan, et al.
Publicado: (2023)

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors
por: Xu, Xiaozheng, et al.
Publicado: (2021)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Impact of SHP2 tyrosine phosphorylation on the development of acquired resistance to allosteric SHP2 inhibitors
por: Franciosa, Giulia, et al.
Publicado: (2023)

Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2
por: Taylor, Julia, et al.
Publicado: (2023)

Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes
por: Lade, Dhanaji M., et al.
Publicado: (2023)

Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching
por: Kim, Chu-Sook, et al.
Publicado: (2016)

A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases
por: Sinthuwiwat, Thivaratana, et al.
Publicado: (2022)

SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses
por: Christofides, Anthos, et al.
Publicado: (2022)

Skeletal malformation and the SHP-2 pathway
Publicado: (2011)

Shp1 in Solid Cancers and Their Therapy
por: Varone, Alessia, et al.
Publicado: (2020)

PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2
por: Xu, Xiaozheng, et al.
Publicado: (2020)

Intraarticular injection of SHP2 inhibitor SHP099 promotes the repair of rabbit full-thickness cartilage defect
por: Sun, Ziying, et al.
Publicado: (2022)

Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine
por: Yarnall, Matthew T.N., et al.
Publicado: (2022)

HvCKX2 gene silencing by biolistic or Agrobacterium-mediated transformation in barley leads to different phenotypes
por: Zalewski, Wojciech, et al.
Publicado: (2012)

SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism
por: McNamara, Jeffrey T., et al.
Publicado: (2021)

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
por: Lumeng, Carey N., et al.
Publicado: (2008)

Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2
por: Park, Hyunju, et al.
Publicado: (2015)

Metabolic phenotyping in people living with obesity: Implications for dietary prevention
por: Blaak, Ellen E., et al.
Publicado: (2023)

Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
por: Mali, Raghuveer Singh, et al.
Publicado: (2012)

ROCKs cause SHP-wrecks and broken hearts
por: Tandon, Panna, et al.
Publicado: (2012)

Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals
por: WU, XUELIANG, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b314tam0u4pttejqqoovfas0tg