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Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats

Stem cell therapies for intervertebral disc degeneration have been demonstrated as a promising strategy. Previous studies have shown that human nucleus pulposus cell- (NPC-) derived exosomes can induce the differentiation of mesenchymal stem cells (MSCs) into NP-like cells in vitro. However, the mec...

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Detalles Bibliográficos
Autores principales: Lan, Wei-ren, Pan, Sai, Li, Hai-yin, Sun, Chao, Chang, Xian, Lu, Kang, Jiang, Chang-qing, Zuo, Rui, Zhou, Yue, Li, Chang-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526523/
https://www.ncbi.nlm.nih.gov/pubmed/31249601
http://dx.doi.org/10.1155/2019/8404168