Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately resulting in...

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Detalles Bibliográficos
Autores principales: Krejciova, Zuzana, Carlson, George A., Giles, Kurt, Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526619/
https://www.ncbi.nlm.nih.gov/pubmed/31109379
http://dx.doi.org/10.1186/s40478-019-0703-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526619/
https://www.ncbi.nlm.nih.gov/pubmed/31109379
http://dx.doi.org/10.1186/s40478-019-0703-9

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