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Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein
Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately resulting in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526619/ https://www.ncbi.nlm.nih.gov/pubmed/31109379 http://dx.doi.org/10.1186/s40478-019-0703-9 |