Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is important in targeting Rabs to specific membranes. He...

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Detalles Bibliográficos
Autores principales: Sanzà, Paolo, Evans, Richard D., Briggs, Deborah A., Cantero, Marta, Montoliu, Lluis, Patel, Shyamal, Sviderskaya, Elena V., Itzen, Aymelt, Figueiredo, Ana C., Seabra, Miguel C., Hume, Alistair N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526710/
https://www.ncbi.nlm.nih.gov/pubmed/30898842
http://dx.doi.org/10.1242/jcs.212035

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