The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

Mutations in C9orf72 leading to hexanucleotide expansions are the most common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A phenotype resembling ALS and FTD is seen in transgenic mice overexpressing the hexanucleotide expansions, but is absent in C9orf72...

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Detalles Bibliográficos
Autores principales: Ho, Wan Yun, Tai, Yee Kit, Chang, Jer-Cherng, Liang, Jason, Tyan, Sheue-Houy, Chen, Song, Guan, Jun-Lin, Zhou, Huilin, Shen, Han-Ming, Koo, Edward, Ling, Shuo-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526867/
https://www.ncbi.nlm.nih.gov/pubmed/30669939
http://dx.doi.org/10.1080/15548627.2019.1569441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526867/
https://www.ncbi.nlm.nih.gov/pubmed/30669939
http://dx.doi.org/10.1080/15548627.2019.1569441

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