Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in HSPB1 cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy. In this study we show that mutations in HSPB1 lead to impairment of macroautophagic/aut...

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Detalles Bibliográficos
Autores principales: Haidar, Mansour, Asselbergh, Bob, Adriaenssens, Elias, De Winter, Vicky, Timmermans, Jean-Pierre, Auer-Grumbach, Michaela, Juneja, Manisha, Timmerman, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526868/
https://www.ncbi.nlm.nih.gov/pubmed/30669930
http://dx.doi.org/10.1080/15548627.2019.1569930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526868/
https://www.ncbi.nlm.nih.gov/pubmed/30669930
http://dx.doi.org/10.1080/15548627.2019.1569930

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